3 edition of Biochemical mechanisms of liver injury found in the catalog.
Includes bibliographies and index.
|Statement||edited by T.F. Slater.|
|Contributions||Slater, Trevor Frank.|
|LC Classifications||RC847 .B56|
|The Physical Object|
|Pagination||xii, 821 p. :|
|Number of Pages||821|
|LC Control Number||77077144|
Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage. Drug-induced liver injury is a cause of acute and chronic liver disease. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents. Certain medicinal agents, when taken in overdoses and sometimes even Specialty: Gastroenterology. Geoff Farrell's research interests are in non-alcoholic steatohepatitis, viral hepatitis, drug-induced liver injury, and liver regeneration. He has published 3 books, including the first on non-alcoholic fatty liver disease, and written more than scientific papers and reviews/chapters and editorials in the fields of hepatology and.
Molecular and biochemical mechanisms of bile duct injury after liver transplantation Proefschrift ter verkrijging van het doctoraat in de Medische Wetenschappen aan de Rijksuniversiteit Groningen op gezag van de Rector Magnificus, dr. F. Zwarts, in het openbaar te verdedigen op maandag 8 december om uur door Carlijn Ineke Buis. The sections that follow emphasize important injury mechanisms, which can be a consequence of metabolism and/or direct cell toxicity of chemicals. These mechanisms include bile acid-induced liver cell injury during cholestasis, pathophysiological effects of mitochondrial dysfunction, and cell damage by reactive oxygen and nitrogen by:
The mechanism of jaundice development, their biochemical characteristic. Jaundice or icterus is the orange-yellow discoloration of body tissues which is best seen in the skin and conjunctivae; it is caused by the presence of an excess of bilirubin in the blood plasma and tissue fluids. Depending upon the cause of an increased plasma bilirubin level, jaundice can be classified as. Drug-Induced Liver Disease, 3rd edition is a comprehensive reference that covers mechanisms of injury, diagnosis and management, major hepatotoxins, regulatory perspectives and much more. Written by highly respected authorities, this new edition is an updated and definitive reference for clinicians and scientists in academia, the pharmaceutical.
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Biochemical mechanisms of liver injury. London ; New York: Academic Press, (OCoLC) Online version: Biochemical mechanisms of liver injury. London ; New York: Academic Press, (OCoLC) Document Type: Book: All Authors / Contributors: Trevor Frank Slater.
Biochemical Mechanisms of Paraquat Toxicity presents the proceedings of the First Iowa Symposium on Toxic Mechanisms that was held from JuneThe symposium brought together a diverse group of investigators consisting of chemists, pharmacologists, pathologists, biochemists, and toxicologists from the United States, Canada, and Europe.
GENERAL MECHANISMS OF DAMAGE. Although major pathways leading to drug-induced liver injury include necrosis and/or apoptosis, a net distinction between these two processes is sometimes difficult and both events often coexist in the same microscopic field.Several factors may influence the hepatocyte response to a toxic insult and the extent of Cited by: The present status of biochemical causes for liver injury is well reviewed here.
The subjects covered are indicative of the interests and approaches of the editor. A unique feature is the inclusion of five chapters (of 20) dealing with the application of.
In this paper, we will summarise our current knowledge of the molecular mechanisms of the pathogenesis of chemical-induced liver injury. More detailed information on the mechanisms of progression of liver disease can be found in other reviews such as those of Henderson and Iredale (Ref.
9) and Guicciardi and Gores (Ref. 10). Mechanisms of liver injury are considered from the points of view of fat accumulation, necrosis and the role of toxic metabolites. The actions of microsomal enzymes in producing such toxic metabolites, or else detoxicating other chemicals, are related to the nutritional control of microsomal enzyme activity and the effects of enzyme by: Biochemical and Cellular Mechanisms of Toxic Liver Injury.
Neil Kaplowitz, M.D. either an immune-mediated attack on the liver or a biochemical effect of. Biochemical mechanisms in drug-induced liver injury: Certainties and doubts Article Literature Review (PDF Available) in World Journal of Gastroenterology 15(39).
The book is a collection of selected clinical and scientific topics divided into two volumes, each divided into two sections.
The first volume treats the cellular, biochemical and immunological mechanisms underlying liver diseases; the second focuses on clinical liver disease pathophysiology and related diagnostics and therapeutic insights.
The biochemical mechanisms behind skeletal muscle soreness and damage with muscular overuse have remained unclear. Recently, however, a growing amount of evidence indicates that free radicals play an important role as mediators of skeletal muscle damage and inflammation.
During exercise, two of the potentially harmful free radical generating sources Cited by: T1 - Mechanisms of liver injury. T2 - An overview. AU - Higuchi, Hajime. AU - Gores, Gregory J. PY - /10/6. Y1 - /10/6. N2 - Liver cirrhosis, an end-result of a wide variety of the liver diseases, is a world wide health problem.
Because of its unique organ system, i.e., portal blood supply, bile formation and enterohepatic circulation Cited by: Liver Diseases Biochemical Mechanisms and New Therapeutic Insights Two Volume Set edited by Shakir Ali.
Liver Diseases presents state-of-the-art information summarizing the current understanding of a range of liver diseases, and reviews some key diagnostic and therapeutic advances. Features: Treats the cellular, biochemical and immunological mechanisms. Open for discussion is a 5-hit working hypothesis, attempting to define key elements involved in injury progression.
In essence, although abundant biochemical mechanisms are proposed for the initiation and perpetuation of liver injury, patients with an alcohol problem benefit from permanent alcohol abstinence by: Biochemical and Cellular Mechanisms of Toxic Liver Injury The latter is due to the occurrence of intracellular stress in the form of biochemical events such as oxidative stress, redox changes.
In this review, we will discuss mechanisms of acetaminophen-induced liver injury in mice and man with a particular focus on the role of inflammation and the inflammasome.
View Show abstract. The first section covers the remarkable advances that have been made in the clarification of biochemical mechanisms connecting oxidative insult to hepatocyte death.
Stimulating new data on the role of free radicals and lipid peroxidation in the development of hepatocellular carcinoma and in liver regeneration appear in the second by: Mechanisms of Hepatotoxicity 1. Mechanisms of Hepatotoxicity Reza Heidari Pharm.D and Toxicology PhD Pharmaceutical Sciences Research Center Shiraz University of Medical Sciences 2.
Introduction Liver plays a key role in detoxifying harmful substances that you may eat, drink, inhale or rub on your skin. Kaplowitz, N. () Biochemical and cellular mechanisms of toxic liver injury. Seminars in Liver Dise - Holt, M.P. and Ju, C. () Mechanisms of drug-induced liver by: Abstract.
The morphological and functional integrity of the liver is vital to the health of the human organism. This essentially depends upon constant maintenance of the numerous biochemical functions of the liver and the diverse metabolic processes occurring in the hepatocytes and sinusoidal liver ensures that approximately.
Evidence that association is independent of both alcohol consumption and changes in other liver function tests suggest that possible mechanisms beyond alcohol neurotoxicity and hepatic dysfunction deserve further investigation (Michael ) The present study was envisioned to carry out Biochemical studies of alcohol induced liver injury in the Author: Upma Agarwal, Ritu Sharma, D.K.
Kansal. ISBN: OCLC Number: Description: pages: illustrations: Contents: Role of Ca2+-mediated endonuclease activation in chemical toxicity / D.J. McConkey, Tak Yee Aw and S. Orrenius --Selective neurotoxicity: problems in establishing the relevance of in vitro data to the in vivo situation / W.N.
Aldridge --Organophosphorus .Written as an advanced text for toxicology students, this book is much more than an introduction and provides in-depth information describing the underlying mechanisms through which toxicants produce their adverse responses.
Links traditional toxicology to modern molecular techniques, important for teaching to graduate courses and professional studies Uses a didactic approach. Despite their limitations, liver biochemical and function tests have many applications in clinical medicine: They provide a noninvasive method to screen for the presence of liver disease.
The serum aminotransferases, for example, are part of panel of tests used to screen all blood donors in the United States for the presence of transmissible.